| 2021-08-24 16:00:41August 24, 2021 | Downingtown East JV vs Pennridge JV (Scrimmage) | 16:00:414:00 pm | JV | 2021 | |
| 2021-09-01 17:30:04September 1, 2021 | Villa Maria JV vs Downingtown East JV (Scrimmage) | 17:30:045:30 pm | JV | 2021 | |
| 2021-09-03 17:15:15September 3, 2021 | Villa Joseph Marie JV vs Downingtown East JV | 17:15:155:15 pm | JV | 2021 | |
| 2021-09-09 17:30:20September 9, 2021 | Downingtown East JV vs Great Valley JV | 17:30:205:30 pm | JV | 2021 | |
| 2021-09-11 11:00:45September 11, 2021 | Owen J. Roberts JV vs Downingtown East JV | 11:00:4511:00 am | JV | 2021 | |
| 2021-09-13 17:30:38September 13, 2021 | Kennett High School JV vs Downingtown East JV | 17:30:385:30 pm | JV | 2021 | |
| 2021-09-15 15:45:40September 15, 2021 | Downingtown East JV vs West Chester East HS JV | 15:45:403:45 pm | JV | 2021 | |
| 2021-09-20 17:30:34September 20, 2021 | West Chester Henderson HS JV vs Downingtown East JV | 17:30:345:30 pm | JV | 2021 | |
| 2021-09-22 17:30:30September 22, 2021 | West Chester Rustin HS JV vs Downingtown East JV | 17:30:305:30 pm | JV | 2021 | |
| 2021-09-25 10:00:29September 25, 2021 | Downingtown East JV vs Conestoga HS JV | 10:00:2910:00 am | JV | 2021 | |
| 2021-09-27 15:30:28September 27, 2021 | Downingtown East JV vs Downingtown West HS JV | 15:30:283:30 pm | JV | 2021 | |
| 2021-09-29 17:30:31September 29, 2021 | Downingtown East JV vs Avon Grove HS JV | 17:30:315:30 pm | JV | 2021 | |
| 2021-10-04 17:30:25October 4, 2021 | Oxford Area HS JV vs Downingtown East JV | 17:30:255:30 pm | JV | 2021 | |
| 2021-10-06 17:30:10October 6, 2021 | Coatesville Area HS JV vs Downingtown East JV | 17:30:105:30 pm | JV | 2021 | |
| 2021-10-12 17:30:16October 12, 2021 | Downingtown East JV vs Bishop Shanahan JV | 17:30:165:30 pm | JV | 2021 | |
| 2021-10-14 17:30:04October 14, 2021 | Unionville HS JV vs Downingtown East JV | 17:30:045:30 pm | JV | 2021 | |
| 2021-10-16 10:00:47October 16, 2021 | Downingtown East JV vs Boyertown HS JV | 10:00:4710:00 am | JV | 2021 | |
| 2021-10-18 17:00:37October 18, 2021 | Downingtown East JV vs Perkiomen Valley JV | 17:00:375:00 pm | JV | 2021 | |
| 2021-10-20 15:45:32October 20, 2021 | Downingtown East JV vs Sun Valley HS JV | 15:45:323:45 pm | JV | 2021 | |
| 2021-10-23 09:00:26October 23, 2021 | Spring-Ford JV vs Downingtown East JV | 09:00:269:00 am | JV | 2021 | |
